k) If an NLS is attached to RanGAP, what effect would that have on accumulation
ID: 147855 • Letter: K
Question
k) If an NLS is attached to RanGAP, what effect would that have on accumulation of lamins in the nucleus? (4 pts) Promote Inhibit No change I) If an NLS is attached to RanGEF, what effect would that have on accumulation of lamins in the nucleus? (4 pts) Promote hbt No change m) If you experimentally manipulate cells such that there is a large excess of free NLS polypeptide compared to molecules of importin, what effect would that have on nuclear import of lamins? (4 pts) Promote Inhibit No changeExplanation / Answer
The GAP of Ran (denoted by RanGAP) is located predominantly in the cytoplasm while GEF of Ran protein is located almost exclusively in the nucleus.
RanGAP NLS (Nuclear Localization Signal) and NESs (Nuclear Exit Signal) facilitate its transport into and out of the nucleus.
k) If an NLS is attached to RanGAP, it would promote the accumulation of lamins in the nucleus.
l) If an NLS is attached to RanGEF, it would also promote the accumulation of lamins in the nucleus.
m) The function of importin is to conduct the translocation of proteins with nuclear localization signals into the nucleus.
So, if there is a large excess of free NLS polypeptide compared to importin, it will have NO EFFECT (NO CHANGE) on nuclear import of lamins as for import of lamins into the nucleus Importins will be required.
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