You are a cytogeneticist in a veterinarian laboratory looking at gamete producti
ID: 148017 • Letter: Y
Question
You are a cytogeneticist in a veterinarian laboratory looking at gamete production in male and female beagles that are producing subpar numbers of offspring and it your job to examine cultured ova and/or sperm for the purpose of looking at the chromosome spreads. You have to notify the veterinarian in charge if you see abnormalities along with your suspicions and what your preliminary diagnosis is. State what the original chromosomal defect is that could have produced this defect. a. In the first case you refer to veterinarian, you see gametes that carry acentric shorter 1. chromosomes and an occasional longer chromosome that appears to have two centromeric restrictions chromosomes (#14 and #22).Explanation / Answer
a. If a chromosome lacks a centromere, it will not be dragged to either pole at anaphase of mitosis and meiosis and will end up not being incorporated into the progeny nucleus. Such acentric chromosomes are not inherited. If a chromosome is dicentric (has two centromeres), it will often be simultaneously dragged to opposite poles at anaphase. This will cause an anaphase bridge to form. These anaphase bridge chromosomes will typically not be incorporated into either progeny cell, depending on the organism under consideration.
b. Chromosomes display a banded pattern when treated with some stains. Bands are alternating light and dark stripes that appear along the lengths of chromosomes. Unique banding patterns are used to identify chromosomes and to diagnose chromosomal aberrations, including chromosome breakage, loss, duplication, translocation or inverted segments. Each chromosome has a characteristic banding pattern that helps to identify them; both chromosomes in a pair will have the same banding pattern.
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