2. Please read the following case study and answer the questions that follow Fal
ID: 149637 • Letter: 2
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2. Please read the following case study and answer the questions that follow Fall 2018 The patient was a female in her eighties with pulmonary hypertension nasal cannula. She had a hospital admission previously for worsening exertion, and chest pain. Chest radiograph was consistent with right given a 14 day course of levofloxacin and discharged to a skilled nursing facility. Three weeks later requiring chronic oxygen by shortness of breath, dyspnea middle lobe pneumonia. She waS she h ad the onset of loose, watery stools, which increased in frequency to more than 10 times per day he had generalized weakness and diffuse abdominal pain and was unable to walk. She also was unable to eat, with several episodes of nausea and vomiting. Her family and social history was significant only for her having moved to a nursing home. On re-admission, approximately three weeks into her diarrheal disease course, she had fever, chills, malaise, myalgia, and dizziness. She had lost five pounds since her prior admission. She was dehydrated with hypotension (82/40). Bacterial cytotoxins were found upon fecal testing, On examination her abdomen was soft, diffusely tender, and mildly distended. She had decreased bowel sounds and an abdominal radiograph showed grossly dilated bowels (megacolon). She was judged to be a poor surgical risk. Over the next four hospital days, her white blood cell counts went up progressively fron 29,000. to i 27,000/. On the fourth day of hospitalization, the patient passed away. Upon autopsy, pseudomembranous colitis lesions were observed on the surface of the colon. (12 points total) What organism do you think was responsible for her gastrointestinal symptoms and death? (1 point) a. of the population carries this organism. Describe three non-cellular innate defenses that keep these infections from causing disease in these carriers? (1.5 points) What innate defense is being compromised that leads to decreased bowel sounds and dilated bowel (megacolon)? How does the reduction of this innate defense exacerbate the disease? (2 points) c. d. What caused the pseudomembranous lesions in the colon? Why could these lesions be life threatening? (2 points) option for this patient, what other non-antibiotic treatment options Knowing surgery was not an could be available for this infection? (1 point) e.Explanation / Answer
a) Bacteria
b) * The skin and cell mucous membrane in the body openings which form external barriers.
* Different defence cells from the white blood cell group (leukocytes)
* Various substances in the blood and in body fluids.
C).
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