BIO2400, Molecular Genetics Exam 2 (This exa 1. B-thalassemia trait (BTT) is a g
ID: 149798 • Letter: B
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BIO2400, Molecular Genetics Exam 2 (This exa 1. B-thalassemia trait (BTT) is a genetic condition resulting in lowered amounts of hemog ondition e manner, the hemoglobin (HbB) B-chain cause the phenotype, Inherited in an autosomal recessiv s sub-classified into 2 forms: the more severe form, thalassemia major (homozygous recessive), and the milder form, thalassemia minor (heterozygous). a) What mode of inheritance is being displayed for B-thalassemia? (5 points) f a woman having tholassemia minor had children with a normal man, what would the probabilities be for the following events? b) a girl is born with the thalassemia minor trait? (5 points) c) a normal girl is born followed by a normal boy? (5 points) d) if the family planned to have 4 children, 1 boy would carry the thalassemia minor trait? (5 points) color and shape of squash are controlled by two (2) sets of genes which each act in an epistatic olor is determined by the W and G genes. The genotypes W-G-and W-gg produce white frui ypes wwG-produce yellow fruit, and the wwgg genotype produces green fruit. ape is determined by the A and B genes. The genotype A-B- produces disk-shaped fruit. S produced by the A-bb and aaB- genotypes and long fruit are produced by the aabb genc ossed a WwGgAaBb plant with a WwGgAabb plant, what proportion of the offspring wo rical? (5 points) 99 white frth yellow fruExplanation / Answer
a. Beta thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically aymptomatic individuals. Beta thalassemias are caused by mutations in the HBB gene on chromosome 11, inherited in an autosomal recessive fashion. The severity of the disease depends on the nature of the mutation.
b. No, 80% of the children would be normal, so girl may not have thalesemia minor.
c. Yes, they may have normal girl and normal boy.
d. There is 10% chance of getting thalesemia minor in children , so out of four, one might get thalesemia minor.
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