QUESTION 1 point possible (graded) The patient was treated with an antibody that

Question

QUESTION 1 point possible (graded) The patient was treated with an antibody that blocks PD-L1. Where is this molecule expressed, and how might it function in the treatment of melanoma? PD-L1 is expressed by immune cells, such as DCs, and non-immune cells, including many cancer cells. Blocking PD-L1 prevents its interaction with PD-1 expressed by T cells, thus relieving a negative regulator of T cell function. O PD-L1 is only expressed by professional antigen presenting cells. Blocking PD-L1 prevents its interaction with PD-1 expressed by naive T cells, thus relieving a negative regulator of T cell function. O PD-L1 is expressed by naive T cells. Blocking PD-L1 prevents its interaction with PD-1 expressed by antigen presenting cells, thus relieving a negative regulator of T cell function. O PD-L1 is expressed by exhausted T cells in the periphery. Blocking PD-L1 prevents its interaction with PD-1 expressed by tumor cells, thus relieving a negative regulator of T cell function.

Explanation / Answer

Answer- PD-L1 is expressed by immune cells, such as DCs, and non-immune cells like natural killer cells, monocytes,including many cancer cells. Blocking PD-L1 prevents its interaction with PD-1 expressed by T cells, thus relieving a negative regulator of T cell function.

How- When PD-L1 binds to PD-1, an inhibitory signal generates which reduces the proliferation of T cells and reduce apoptosis. Human melanoma cancer cells express high level of PD-L1, and if we block this, we reduce growth of a tumor. thus it is effective in treatment of melanoma.

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