PROBLEM 6-2 Paragraph Organization The following paragraph is about types of glu

Question

PROBLEM 6-2 Paragraph Organization The following paragraph is about types of glutamate receptors. Although the paragraph has a topic sentence, the remaining sentences of the para graph do not follow logically from the topic sentence. Add a sentence after the topic sentence to fulfill the expectations of the reader. (What does the reader expect to read about after reading the topic sentence?) Reorganize sentence 2 to make it parallel to sentence 3. 1 Ionotropic glutamate receptors fall into two general categories (7, 8). 2 When NMDA receptors are activated by N-methyl-D-aspartate (NMDA), ion channels are opened, allowing ions to rush into the cell and thus cause an excitatory postsynaptic potential. 3 Non-NMDA receptors like PCP bind to kainate and quisqualate only and prevent ion flow and an excitatory post- synaptic potential, even in the presence of NMDA.

Explanation / Answer

NMDA receptors are activated by NMDA while Non- NMDA receptors like PCP bind to kainate and quisqualate. The NMDA receptors on binding to NMDA causes the ion channels to open up and allow the ions to rush into the cell and thus cause an excitatory postsynaptic potential.

However, the Non-NMDA receptors prevent the ion flow and an excitatory postsynaptic potential, even in the presence of NMDA. So, the NMDA receptors promote the synaptic transmission while non-NMDA receptors like PCP inhibits the neurotransmission.

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