ground information: Following tissue damage, both cels and the extrace aced. Two
ID: 151123 • Letter: G
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ground information: Following tissue damage, both cels and the extrace aced. Two growth factors called PDGF and TGF-B are critical for thisn fioroblast elets at the site of a wound and signal through receptor tyrosine onds to these growth factors by changing numerous functiors. both cels and the extracelhular matrix need kinases on a fibroblast. The cell Both of these growth factors are proteins. Whry do they need to signal through a red so you to 1. gh a receptor on the think about the chemical properties of proteins and the chemical properties af the membrane. properties of ahking for to 2. How might changes in cell movement occur in response to PDGF signaling? You sho the PDGF signal and what molecules might be involved in responding to it and conned how the cell might actualily move (the slides are a good place to start) 3. Once the fibroblast cells arrive at the wound, they begin to mutiply there to replace the damaged skin cells. What response to the signaling pathway causes the cel to divide? Be as specific as possible. Suppose FIVE PDGF receptors are activated on a single cell. How many ERK activated? 4. Exactly five More than five i. Less than five b. Explanation:Explanation / Answer
(1)Receptors are required in case of lipophobic ligands which cannot cross the lipid bilayer(cell membrane).Because cell membrane contain lipid molecules and they do not allow the entry of hydrophilic molecules in the cell.Hence,receptors help them to function.
(2)The binding of PDGF binds to PDGFR ligand binding pocket located in second or third immunoglobulin domains.These receptors are dimerised and autophosphorylated i.e switched on which activates PI3k pathway in the cell which is mainly responsible for cell migration.
(3)Fibroblast growth factor(FGF)
(4)Exactly five
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