. Suppose you treated the wound with a general kinase inhibitor. How would this
ID: 151156 • Letter: #
Question
. Suppose you treated the wound with a general kinase inhibitor. How would this affect the cellubar response to POGF and TGF-B? Choose at least five spedific events that would be affected. 8. One of the primary responses to cell signaing is changes in gene transoription. List at least three different ways cells can regulate which genes are transcribed. 9. This entire process requires numercus forms of protein regulation - the proteins are already synthesized, but their activity changes following the regulatory modification or interaction. Descrnbe at least three protein modifications that occur during the cell's response to these growth factors. Include both the modification or irteraction as well as the function. 10. Cell signaling does not cause changes to the nucleotide sequence, but it can cause changes to the DNA. Descnbe at least two changes that can oocur to the DNA, ether chemical or structural, that can affect a cel's behavior.Explanation / Answer
7. Activity of platelets derived factor and transforming growth factor will decreased as the wound is applied with general kinase inhibitor. This is because, kinase inhibitor will block the activity of growth factor proteins. Five specific events are
a. Immune reaction in body
b. Wnt signalling pathway
c. Hormone signalling
d. Cell divisions
e. Blood vessels differentiation
8. Three ways by which cell can regulate the transcription of gene are
a. Inducing activator and repressor
b. By changing the specific factor like rho protein that help RNA polymerase to bind with promoter.
c. By changing the promoter sequence
9. Three proteins modification are
a. When antibody is interact with antigen, it produces some chemicals that kill antigen
b. Second messanger get activated like cAMP that activate the signal transduction pathway.
c. Wound healing is enhanced when growth factor in inhibited.
10. Changes in DNA occur as
a. when signalling molecule interact with receptor molecule, they alter the transcription by the process called transduction
b. When signaling molecule activate the receptor, new product is transcribed.
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