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The hypothetical protein AK-7 is involved in the absorption of short chain fatty

ID: 15565 • Letter: T

Question

The hypothetical protein AK-7 is involved in the absorption of short chain fatty acids by epithelial cells in the human large intestine. These short chain fatty acids are produced by E, coli bacteria found in the large intestine. An allele of this protein has the sequence: 3'-TACAATTAGCATGGTGTGGGCACGCGCTCTTTAGACGAAAGGCCCATT-5' Another allele was determined to differ from the first allele by having five different codons in its mRNA sequence without affecting the protein's primary structure. Explain why this can happen. Now, you need to duplicate the second allele by designing an mRNA where any five codons are replaced without affecting the primary structure of AK-7.

Explanation / Answer

This can happen because codons differing in the third position can still code for the same amino acid. Example:Both UGU and UGC code for cysteine.

3'-TACAACTAACAGGGGGTAGGCACGCGCTCTTTAGACGAAAGGCCCATT-5'

I highlighted the five changes in red.