1. Assume a person suffered a hemorrhage and lost 1.5 liters of blood, causing M

Question

1. Assume a person suffered a hemorrhage and lost 1.5 liters of blood, causing MAP to fall to 80 mmHg.

A. Name an enzyme released by cells in the juxtaglomerular apparatus whose activity would increase and show the reaction it would catalyze (3 pts)


_____________________ ?? _____________________

_____________________________


Name the enzyme on the line above

B. the product of the above reaction is, in turn acted on by an enzyme in the lungs and kidneys to convert it into and active hormone (3 pts)

Named _______________________
In fewer than 10 words list 2 direct effects of the hormone you listed above (
a.


b.


2. If in an average person’s cardiac output at rest is 6 liters/min, hematocrit is 45%, GFR = 144ml/min, approximately how many ml of blood plasma would you expect to enter the peritubular capillaries each minute?

__________ml/min (2 pts)

3. Inulin is a substance that is filtered in the glomerulus but it is not reabsorbed or secreted in the nephron. If the plasma concentration of inulin is
9 mg/100 ml; urine volume is 62.5 ml/hr and urine inulin concentration is
12 mg/ml, then

GFR = ________ml/min (2 pts)

Explanation / Answer

1.Renin, an enzyme produced in the juxtaglomerular apparatus of the kidney, catalyzes the conversion of angiotensinogen (an inactive precursor peptide) to angiotensin I. b.Angiotensin I undergoes further enzymatic conversion by angiotensin-converting enzyme (ACE) to produce angiotensin II. Angiotensin II acts via the angiotensin receptor to stimulate the release of aldosterone by increasing the transcription of aldosterone synthase.

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