Cyclic AMP can activate the synthesis of some enzymes. It is likely that the mec

Question

Cyclic AMP can activate the synthesis of some enzymes. It is likely that the mechanism involves : A. binding of free cAMP to a nucleotide sequence in the promoter region of the gene for the enzyme. B. phosphorylation of an acidic protein which is bound to the gene for the enzyme. C. phosphorylation of a glucocorticoid receptor protein which then migrates to the nucleus and activates the gene for the enzyme. D. binding of cAMP to a protein kinase regulatory subunit which migrates to the nucleus, binds to chromatin, and activates the gene for the protein. E. phosphorylation of initiation factor IF-2 which stimulates translation of the mRNA for the enzymes.

Explanation / Answer

D. Binding of cAMP to a protein kinase regulatory subunit which migrates to the nucleus, binds to chromatin, and activates the gene for the protein.

Without cAMP PKA is catalitically state when it binds with cAMO it becomes active and Activation of PKA phosphorylates an number of other protein.

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