3/5/2017 11:55 PM CA 6.6/10 2/27/2017 09:31 PM Gradebook Print Calculator Period

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3/5/2017 11:55 PM CA 6.6/10 2/27/2017 09:31 PM Gradebook Print Calculator Periodic Table Question 27 of 30 Map det Genetics: A Conceptual Approach 6th Edition MHE/Freeman eserted by Sapling Learnin Zidovudine (AZT) is a drug used to treat patients with acquired immunodeficiency syndrome (AIDS). AZT works by blocking the reverse transcriptase enzyme used by the human immunodeficiency virus (HIV), the causative agent of AIDS. What type of transposable elements would be affected by AZT and what would be the most likely effect? All types of retrotransposons would be blocked at the reverse transcription step n elements that transpose through a copy-and-paste mechanism would be blocked at the replication step. Transposable elements that use an RNA intermediate for transposition would be affected, as the RNA intermediate would not be able to be converted into DNA. LTR retrotransposons only would be blocked at the reverse transcription step. All transposable elements would be affected as they would no longer be able to transpose to a new location. A Previous ® Give Up & View Solution Check Answer Next Exit 8 Hint

Explanation / Answer

Azidothymidine, AZT, is a thymidine analogue which is prototype of nucleoside reverse transcriptase inhibitor. This zidovudine triphosphate selectivity inhibits viral reverse transcriptase. The single stranded viral RNA is converted to double standard proviral RNA by the enzyme reverse transcriptase.this enzyme is inhibited by zidovudine triphosphate.hence Option 3 is answer. Anemia and neutropenia are the most important and dose related adverse effects of zidovudine.

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