Please answer the question thoroughly Some voltage-gated channels can inactivate

Question

Please answer the question thoroughly

Some voltage-gated channels can inactivate while some ligand-gated channels can desensitize. Describe the difference between inactivation and desensitization of an ion channel. Give one concrete example of a channel that is known to inactivate (besides the typical action potential Na* channel discussed in class) and one concrete example of a channel that is known to desensitize (besides the glutamate channel discussed in class). You will need to search the literature.

Explanation / Answer

Answer:

a) In a voltage-gated ion channel, Inactivation is the closing of the inactivation gate when a channel enters a state in which activation does not occur even though the activation current is present. As with activation, inactivation occurs in response to the membrane potential becoming more positive.

In a ligand-gated ion channel, neurotransmitter receptors regulating the activity of ion channels. Ligand-induced desensitization occurs when Neurotransmitter receptors are known to become unresponsive to the type of neurotransmitter they receive when exposed for extended periods of time.

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