Which of the following is true? hTR behaves like a tumor suppressor. Overexpress

Question

Which of the following is true? hTR behaves like a tumor suppressor. Overexpression of dominant negative hTERT protects against crisis. Low hTERT expression is indicative of a poor prognosis in pediatric neuroblastomas. Over-expression of hTR can prevent cancer cell growth. hTERT behaves like a proto-oncogene. Which of the following are true (select all that are true)? The TRAP assay detects telomerase activity by providing a primer that includes telomeric repeats to act as a template for any telomerase in the sample. The catalytic subunit of telomerase is closely related to the DNA polymerases of tumor viruses like HPV. hTR is a long RNA with a template region the length of a typical telomere (~5 kb). The hTR RNA is present in most cell types, but hTERT is absent In most non immortalized cell types. Expression of telomerase shortens the time before cells enter crisis.

Explanation / Answer

ANSWER:

TELOMERASE: Telomerase is called terminal transferase .A telomere is a region of repetitive sequences at each end of a eukaryotic chromosomes in most eukaryotes.

1) Overexpression of dominant negative hTERT protects against crisis.

2) a)The hTR RNA is present in most cell types ,but hTERT is absent in most non immortalized cell types.

b) Expression of telomerase shortens the time before cell enter crisis.

c) hTR is a long RNA with template region the lenght of a typical telomere(-5kb).

d) The catalytic subunit of telomerase is closely related to the DNA polymerase of tumor virus like HPV.

e)The trap assay detects telomerase activity by providing a primer that includes telomeric repeats to act as a template for any telomeras in the sample.

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