Please help me answering these questions. Which of the following peptide sequenc

Question

Please help me answering these questions.

Which of the following peptide sequences would most likely form an -helical structure?

Gly-Ile-Trp-Leu-Ile-Ile-Phe-Gly-Val-Val-Ala-Gly-Val-Ile-Gly-Trp-Ile-Leu-Leu-Ile

Gly-Pro-Hyp-Gly-Pro-Met-Gly-Pro-Ser-Gly-Pro-Arg-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly

Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Pro-Leu-Leu

Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Cys-Leu-Leu

Which of the following peptide sequences could have at least one disulfide bond?

Gly-Ile-Trp-Leu-Ile-Ile-Phe-Gly-Val-Val-Ala-Gly-Val-Ile-Gly-Trp-Ile-Leu-Leu-Ile

Gly-Pro-Hyp-Gly-Pro-Met-Gly-Pro-Ser-Gly-Pro-Arg-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly

Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Pro-Leu-Leu

Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Cys-Leu-Leu

Which of the following peptide sequences would most be part of a fibrous protein found in cartilage?

Gly-Ile-Trp-Leu-Ile-Ile-Phe-Gly-Val-Val-Ala-Gly-Val-Ile-Gly-Trp-Ile-Leu-Leu-Ile

Gly-Pro-Hyp-Gly-Pro-Met-Gly-Pro-Ser-Gly-Pro-Arg-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly

Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Pro-Leu-Leu

Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Cys-Leu-Leu

Gly-Ile-Trp-Leu-Ile-Ile-Phe-Gly-Val-Val-Ala-Gly-Val-Ile-Gly-Trp-Ile-Leu-Leu-Ile

Gly-Pro-Hyp-Gly-Pro-Met-Gly-Pro-Ser-Gly-Pro-Arg-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly

Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Pro-Leu-Leu

Gly-Met-Trp-Pro-Glu-Met-Cys-Gly-Glu-Pro-Ala-His-Val-Arg-Asp-Tyr-Cys-Leu-Leu

Explanation / Answer

Question 1.

Proline is an amino acid which when present perturb the alpha-helix, due to which proline is present at the end of the chain. So among all the option a doesn't have proline so answer will be option a

Question 2.

Disulfide linkage is formed between two residues of Cysteine. If we look at all the option then we will find that only option D has two cysteines which make the only peptide in the given option. SO answer is option D

question 3. College protein has maximum proportion of Glycine, proline and hydroxyproline which generally present in glycine-proline-X w and glycine-X-hydroxyproline where X is any amino acid except the three amino acids mentioned.

By going through all given option only B fits in that criteria

So answer will be option B

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