Gluconeogenesis 1. What is the metabolic logic of reciprocal regulation of the g

Question

Gluconeogenesis

1. What is the metabolic logic of reciprocal regulation of the glycolytic and gluconeogenic pathways by citrate?

2. Consuming large amounts of alcohol when blood glucose levels are low can lead to hypoglycemia due to low rates of gluconeogenesis. Considering that ethanol is oxidized to acetaldehyde by the enzyme alcohol dehydrogenase (ADH), how do you explain the inhibitory effect of alcohol consumption on gluconeogenesis and the subsequent hypoglycemia?

Explanation / Answer

1.the two pathways glycolysis and Gluconeogenesis does an important function of degrading or synthesising glucose in response to energy demand by the cell.the term reciprocal regulation means same regulatory molecule has opposing effect on two enzymes that control a shared step in two reaction. Like in this case when energy is less in the cell than AMP level is high leading to activations of PFK ie more flux of through glycolysis where vice versa happens in gluconeogenesis ie decreased flux and inhibition of FBPAse1. So the pyruvate generated by glycolysis can be used for energy conservation whereas glucose synthesis is shut dowm resulting in I build of pyruvate.

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