With appropriate symbols, describe the following chromosome rearrangements: 3) A

Question

With appropriate symbols, describe the following chromosome rearrangements: 3) A deletion in region 2, band 5 in the long arm of chromosome 4. 4. inversion two breaks in the same arm in the long arm of chromosome 6, region ntric ith 1, with break points in bands 2 and 6. 5 Translocation of the long arm of chromosome 21 to the short arm of chromosome 1 with the retention of the 14 centromere. Assume a break in the short arm of chromosome 14 at region 1, band 1 and the loss of the entire short arm of 21. The chromosome resulting from this translocation is properly referred to as a chromosome 6 A pericentric inversion in chromosome 2 with break points in region 1, band 4 of the short arm and region 2, band 3 of the long arm. 7. Studies in recent years have shown that a number of forms of cancer are associated with specific structural chromosome aberrations. For example, chronic myelogenous leukemia CML) is as- sociated with the so-called Philadelphia chromosome CPh). The defective chromosomes in CML occur only in white blood cells and involve a reciprocal translocation Gexchange of segments between the long arms of chromosomes 9 and 22 Gsee Figure 10.4). Careful studies indicate that

Explanation / Answer

3) A deletion in region2, band 5                 in the long arm of chromosome 4:

Answer: The symbol for this chromosomal rearrangement is del(4)(q25) where del represents deletion 4 indicates chromosome number q stands for long arm of chromosome and 2 and 5 represents region and band respectively.

4) Paracentric inversion (with two breaks in the same arm) in the long arm of chromosome 6, region 1, with break points in bands 2 and 6.

Answer: The symbol for this chromosomal rearrangement is inv(6)(q126)

5) Translocation of the long arm of chromosome 21 to the short arm of chromosome 14 with the retention of the chromosome 14 centromere.     The symbol for this chromosomal rearrangement is t(14;21)(pq)(14p11)

The chromosome resulting from this translocation is properly referred to as a ___Robertsonian translocation____________ chromosome.

6) A pericentric inversion in chromosome 2 with breakpoints in the region1, band 4 of the short arm and region 2, band 3 of the long arm.

The symbol for this chromosomal rearrangement is inv(2)p14q23

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