Which of the following statements about transport of proteins into mitochondria

Question

Which of the following statements about transport of proteins into mitochondria is incorrect?

a) The signal peptidase enzyme will remove the signal sequence as soon as the protein has been imported into these organelles

b) After a protein moves through the translocator in the outer membrane, the protein then must diffuse in the lumen in order to contact a protein translocator in the inner membrane

c) The signal sequence on proteins that belong in these organelles is recognized by a receptor protein in the outer membrane of these organelles

d) Proteins that are transported into these organelles are unfolded as they are being transported

Explanation / Answer

Q. Which of the following statements about transport of proteins into mitochondria is incorrect?

Answer: b) After a protein moves through the translocator in the outer membrane, the protein then must diffuse in the lumen in order to contact a protein translocator in the inner membrane

description: Protein Import into Mitochondria have two path one in the outer membrane and the other in the inner membrane.

The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane.TOM works in conjunction with the translocase of the inner membrane (TIM) to translocate proteins into the mitochondrion.Mitochondria are surrounded by two biological membranes.

The outer mitochondrial membrane contains two major translocators, the TOM40 (TOM) and TOB complexes for protein translocation across and insertion into the outer membrane. The TOM40 complex functions as an entry gate for most mitochondrial proteins, and the TOB complex as a specialized insertion machinery for beta-barrel membrane proteins. To handle loosely folded or unfolded precursor polypeptides, those translocators cooperate with chaperones in the cytosol and intermembrane space and exhibit chaperone.

So in reference of mentioned statment is incorrect beacuse it giving us wrong information about diffusion of protein in Lumen "protein then must diffuse in the lumen in order to contact a protein translocator in the inner membrane".

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