During SRP-mediated secretion, an N-terminal ____ found on a newly synthesized o

Question

During SRP-mediated secretion, an N-terminal ____ found on a newly synthesized or ____ polypeptide is recognized by SRP, which is a complex between a protein called ____ and an sRNA called ____. The binding of SRP to the SS causes the ribosome to stall and the entire complex is moved closer to the cell membrane. Since the process of synthesizing the protein and its insertion into the membrane is coupled, this entire process is called ____. Some proteins can insert themselves into the membrane without the assistance from other proteins. However, in other situations, the SRP complex delivers the growing protein to a membrane-associated shuttle protein called ____, which brings the SRP to a complex called the ____ translocon.

Explanation / Answer

N - terminal Signl sequence

or Nacent

SRP-SR-GTPase

RNC (ribosome nacent chain complex)

ER targeting

Sec61

Sec62

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