Our growing understanding of how proteins fold allows researchers to make predic

Question

Our growing understanding of how proteins fold allows researchers to make predictions about protein structure based on primary amino acid sequence data. I A H T Y G P F E A A M C K W E A Q P D G M E C A F H R

1. Some amino acids are less commonly found in helices. Describe one amino acid that is not prevalent in helices and describe the property and explain why this property causes the decreased prevalence.

2. In helices positively charged amino acids are often found three to four residues away from negatively charged amino acids. Why?

Explanation / Answer

1.Proline is the less common amino acid found in alpha-helices because of its rigid cyclic sidechain which disrupt the helical confirmation.Proline can't participate in intra-helical hydrogen bonding because it lacks hydrogen atom on its amide nitrogen.

2. In helices positively charged amino acids are often found three to four residues away from negatively charged amino acids. It permit the formation of ionic interaction between them and two aromatic amino acids are often similarely spaced, resulting in the hydrophobic interaction.

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