1) Which one of the TCA reactions has a mechanism that involves the use of thiam

Question

1) Which one of the TCA reactions has a mechanism that involves the use of thiamin pyrophosphate and lipoic acid?

a) 1

b) 3

c) 4

d) 6

2) The substrate level phosphorylation that occurs in the succinyl-CoA synthetase reaction is largely driven by what chemical event?

a) Oxidation of the thiol ester

b) Resonance stabilization of the resulting carboxylic acid

c) Release of CO2

d) Resonance stabilization of CoA

3) Gluconeogenesis and fatty acid synthesis share two mechanistically very similar reactions:

a) Both utilize the addition of CO2 using ATP and its subsequent release to overcome an otherwise thermodynamically unfavorable process

b) Both use a TPP mediated reaction for the release of CO2, driving an important reaction forward

c) Both involve the formation of an enediol intermediate to move a carbonyl over by one carbon

d) Both utilize substrate level phosphorylation to generate ATP

4) There are mechanistic similarities between the pentose phosphate pathway and the TCA cycle. These include:

a) Biotin dependent decarboxylation in both pathways

b) Substrate level phosphorylation involving resonance stabilization of a carboxylic acid

c) NAD+ mediated oxidation followed by beta-decarboxylation in both pathways

d) b and c

roblem is worth the same) id 15386986 My ASU Colleges course ASU Home 2a repositioned in COO group oxidized arbenyt, which in turn tacilitates stabilizing carbanion by formed on adjacent carbon. ketoglutarate

Explanation / Answer

1). TPP works as a coenzyme in many enzymatic reactions like Pyruvate dehydrogenase

so option, a) 1

2). d) Resonance stabilization of CoA

3). a) Both utilize the addition of CO2 using ATP and its subsequent release to overcome an otherwise thermodynamically unfavorable process

4).

b) Substrate level phosphorylation involving resonance stabilization of a carboxylic acid

c) NAD+ mediated oxidation followed by beta-decarboxylation in both pathways

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.