You are trying to map the location of a gene that causes a childhood deafness di

Question

You are trying to map the location of a gene that causes a childhood deafness disorder. Although you know it is not X-linked, you know nothing more about the gene's location. Your plan is to find the children of informative testcross matings, genotype the children using a SNP array, and map based on estimated genetic distance to linked SNP markers. You learn about a family that has a large number of cases of the disorder. What mode of inheritance best describes this disease? Circle one. recessive autosomal dominant autosomal Circle the children of all informative matings in the pedigree that you would include in your study.

Explanation / Answer

1) It is autosomal dominant disease because according to this pedigree there is no skip of generation and in autosomal dominant both affected parents may have unaffected child.

2) I will include II-3,III-6,III-10,IV-7 children for my study.

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