You are using QTL mapping to find the locations of genes contributing to variati

Question

You are using QTL mapping to find the locations of genes contributing to variation in obesity in mice. You cross a high obesity mouse with a low obesity mouse, cross the F1, and genotype and measure weight in F2. F2 mice with the A allele for marker e88VF.12 have a minimum weight of 21 g, an average weight of 24g, and a maximum weight of 28g. F2 mice with the B allele for marker e88VF.12 have a minimum weight of 12g, an average weight of 16g, and a maximum weight of 20g. What is the strength of association for the e88VF.12 marker?

Explanation / Answer

A allele: 21g 24g 28g = difference is 3 g

B allele: 12g 16g 20g = difference is 4 g

The strength of association for the e88VF.12 marker is 12 g.

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