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You are stuyding a water soluble protein that functions in the ER lumen. Based o

ID: 167927 • Letter: Y

Question

You are stuyding a water soluble protein that functions in the ER lumen. Based on that information, which of the following statements about your protein must be correct?

You are stuyding a water soluble protein that functions in the ER lumen. Based on that information, which of the following statements about your protein must be correct?

a-The protein must contain a hydrophobic stop-transfer sequence b-The protein has a C-terminal seqeunce that binds to SRP c-Once the signal sequence from your protein has been cleaved from the protein, it will be degraded. d-Only free cytosolic ribosomes can be bound to the the mRNA for your protein.

Explanation / Answer

Answer: a, b, c

Explanation: The hydrophobic signal sequence functions as a stop-transfer sequence based on its location. The SRP begins scanning an unfolded poplypeptide at the N-terminal sequence, for hydrophobic segments. It then moves towards the C terminus. Free as well as bound ribosomes are involved in protein synthesis. After its release, the signal sequence is degraded by protease activity.

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