An allosteric inhibitor: A) decreases the K_M of the enzyme. B) binds to a secon

Question

An allosteric inhibitor: A) decreases the K_M of the enzyme. B) binds to a second site of an enzyme and preferentially stabilizes the low-affinity conformation. C) binds to a second site of an enzyme and preferentially stabilizes the high-affinity conformation. D) helps the substrate bind to the enzyme more tightly. E) binds to the substrate specificity pocket of an enzyme to prevent the substrate from binding. An enzyme operates at its maximal velocity when: A) It is half-bound to substrate B) The concentration of substrate is low relative to the K_M. C) Substrate levels are very high. D) The total enzyme concentration is equal to the concentration of the enzyme-substrate complex. E) C and D

Explanation / Answer

ANSWER:-
1.
b.binds second site of an enzyme preferentially low stabilize affinity
Allosteric enzymesareenzymesthat change theirconformational ensembleupon binding of aneffector, which results in an apparent change inbinding affinity at a different ligand binding site. The kineticproperties of allosteric enzymes are often explained in terms of aconformational changebetween a low-activity, low-affinity"tense" or T state and a high-activity, high-affinity "relaxed" or R state. These structurally distinctenzymeforms have been shown to exist in several known allosteric enzymes.
2.
E) c and d
Enzymes are protein molecules that act as biological catalysts by increasing the rate of reactions without changing the overall process. They are long chain amino acids bound together by peptide bonds. Enzymes are seen in all living cells and controlling the metabolic processes in which they converted nutrients into energy and new cells. Enzymes also help in the breakdown of food materials into its simplest form. The reactants of enzyme catalyzed reactions are termed as substrates. Each enzyme is quite specific in character, acting on a particular substrates to produce a particular products. The central approach for studying the mechanism of an enzyme-catalyzed reaction is to determine the rate of the reaction and its changes in response with the changes in parameters such assubstrate concentration, enzyme concentration,pH, temperature etc .This is known as enzyme kinetics.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.