Which of the following proteins is NOT encoded by a proto-oncogene? Src Ras Smad

Question

Which of the following proteins is NOT encoded by a proto-oncogene? Src Ras Smad4 Myc Mutations in two important cancer-critical genes, encoding p53 and Rb. respectively, are commonly found in cancers. What type of mutations are these usually expected to be? Loss-of-function mutations in both genes Loss-of-function mutation in p53 and gain-of-function mutation in Rb Gain-of-function mutation in p53 and loss-of-function mutation in Rb Gain-of-function mutations in both genes In general, which of the following sequential barriers to metastasis is the easiest to overcome for cancer cells? Vessel entry through acquisition of local invasiveness Exit from the blood into a remote tissue or organ Survival of cells in the foreign tissue Initial growth of cells In the foreign tissue Persistence of growth in the remote site

Explanation / Answer

2. Smad 4

It is coded by SMAD Loss of functionin gene.

3.loss of function mutations in both the genes.

4. vessel entry through acquisition of local invasiveness.

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