You have found a family in Brookings in which some members are suffering from an
ID: 171179 • Letter: Y
Question
You have found a family in Brookings in which some members are suffering from anemia. Their DNA isolated and the alpha hemoglobin gene was sequenced. Below are the DNA sequences for the 5' end of the non-template strand encoding alpha-hemoglobin. Brookings: 5'-ACGTTATGCCCGTACTGCCAGCTAACTGCTAAAGAACAA-3' Normal: 5'-ACGTTATGCCCTACTGCCAGCTAACTGCTAAAGAACAA.....-3' What type of mutation is present in the Brookings family? Starting from the first start codon you come to, what are the codons in the translated portion of the mRNA transcribed from the normal and mutant genes? What are the amino acids in the sequences for the Bemidji family and normal polypeptides?Explanation / Answer
Mutations leading to qualitative alterations in haemoglobin, the missense mutation in the -globin gene that causes sickle cell anaemia is the most common. The mutation causing sickle cell anaemia is a single nucleotide substitution (A to T) in the codon for amino acid 6. The change converts a glutamic acid codon (GAG) to a valine codon (GTG). The form of haemoglobin in persons with sickle cell anaemia is referred to as HbS.
A codon is a series of 3 bases in mRNA that specifies a particular amino acid. Starting fromthe first condon we will get ACG]AGC]CCG]ACG]CCA]GCA]ACG]CAA]AGA]CAA.
amino acids in the sequence is
Threonine, serine, proline, threonine, proline, alanine, threonine, glutamine, serine, histidine
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