In contrast to the leading strand, the lagging strand is synthesized as a series

Question

In contrast to the leading strand, the lagging strand is synthesized as a series of segments called Okazaki fragments. The diagram below illustrates a lagging strand with the replication fork off-screen to the right. Fragment A is the most recently synthesized Okazaki fragment. Fragment B will be synthesized next in the space between primers A and B. Indicate the sequence of events in the production of fragment B, with 1 being first and 5 being last in the order. (Note that pol I stands for DNA polymerase and pol III stands for DNA polymerase III.) primer A space for fragment A fragment B primer B replication fork Adapted from Biology by Campbell and Reece 2008 Pearson Education, Inc. pol III binds to 3' end of primer B pol I binds to 5' end of primer A 2 C. DNA ligase links fragments A and B 3 D. pol I replaces primer A with DNA E. pol III moves 5' to 3", adding DNA nucleotides to primer B 5

Explanation / Answer

The correct sequence of events for lagging strand synthesis:

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