Cells that pass through the G1-S checkpoint enter the cell cycle and, in general

Question

Cells that pass through the G1-S checkpoint enter the cell cycle and, in general, divide. From our lecture on Tuesday 12/6 and Figure 24-19, you know that Rb controls the G1-S checkpoint . Rb normally inhibits passage of the cell into S-phase, by binding to and inhibiting a transcription factor called E2F. When active, E2F will transcribe genes that are involved in DNA synthesis and cellular division. Which of the following mutations would lead to cell proliferation that is not regulated by the G1-S checkpoint?

1. Inactivated E2F

2. Hyperactivated Rb

3. E2f that is hyperactive, but still can be inhibited by R2

4. Inactivated Rb

Explanation / Answer

Inactivation of E2F would lead to cell proliferation that is not regulated by the G1-S checkpoint.

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