Many conditional homozygous deletions produce a tumor phenotype. Which of the fo
ID: 174821 • Letter: M
Question
Many conditional homozygous deletions produce a tumor phenotype. Which of the following descriptions is incorrect?
MDR1-/- mice are tumor prone because they are unable to pump toxins out of cells
MGMT-/- mice are tumor prone because they cannot directly repair alkylated (methyl, ethyl, etc) nucleotides
DNA polymerase-associated exonuclease -/- mice are tumor prone because they have ~100 times more unrepaired errors than wild-type mice during each round of DNA replication
BRCA1-/- mice are tumor prone because they can only repair double-strand breaks by non-homolgous end joining
mucin-/- mice are tumor prone because they are incapable of asymmetric DNA strand allocation during stem cell replication
A.MDR1-/- mice are tumor prone because they are unable to pump toxins out of cells
B.MGMT-/- mice are tumor prone because they cannot directly repair alkylated (methyl, ethyl, etc) nucleotides
C.DNA polymerase-associated exonuclease -/- mice are tumor prone because they have ~100 times more unrepaired errors than wild-type mice during each round of DNA replication
D.BRCA1-/- mice are tumor prone because they can only repair double-strand breaks by non-homolgous end joining
E.mucin-/- mice are tumor prone because they are incapable of asymmetric DNA strand allocation during stem cell replication
Explanation / Answer
Ans
*Choice A is incorrect
MDR1 is helpful in removing cellular toxins and preventing damage.
*Choice B is incorrect
MGMT has no known mutations and it is not likely to cause cancer.
* Choice C is correct.
Mucin-/- mice are tumor prone as they cannot produce to protect intestinal cells from poisonous
gut contents.
* Choice D is incorrect.
Homology directed repair wants both BRCA 1 and BRCA 2. Deficiency of BRCA1 or BRCA2 in cells makes them carcimogen sensitive.
*Choice E is incorrect.
DNA Polymerase corrects 99% errors with proof reading exonuclease activity.
.Homology directed repair wants both BRCA 1 and BRCA 2. Deficiency of BRCA1 or BRCA2 in cells makes them carcimogen sensitive.
*Choice E is incorrect.
DNA Polymerase corrects 99% errors with proof reading exonuclease activity.
Related Questions
drjack9650@gmail.com
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.