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Question: F16 ETX 101 Final Student Number Q1A. Describe the...

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can you answer all follow this question? if you can, plz answer the benzopyrene?

F16 ETX 101 Final Student Number Q1A. Describe the biologiea the chemicals below (Paraquat, Malathion or Benzo(a)pyrene) once it has been eaten by a mamma (such a description, be sure to provide specific human). In addition, in your toxicity is information about the mechanism y which the chemical causes and what the toxic form of the chemica Fina I metabolites of the chemical show two phase and name the specific metabolic enzyme reaction in You may use a flow diagram to help with your description if you desire (its not required however). (20 Points) H3C-O COOCH Ha C-O HaC N-CH -COOCH 5 Malathion Benzo (a)pyrene Paraquat Log Kow 2.70 Log Kow 4.50 Log Kow 6.13

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Paraquat is a viologen i.e. a toxic bipyridinium derivative. It is widely used as a herbicide. Because of its non-selective nature, it also destroys the plant life. Not only this, it is also toxic to humans and animals. It has also been linked to Parkinson’s disease.

Malathion is an organophosphate insecticide. It is used as pesticide in agriculture. It inhibits cholinesterase by binding irreversibly to serine residues. It deactivates the enzyme. This leads to accumulation of acetylcholine at synapse.

Benzo[a]pyrene (BaP) is formed due to incomplete combustion at high temperatures and found in coal tar and tobacco smoke etc. it has the formula C20H12. It comprises of a benzene ring fused to a pyrene. BaP affects brain function by diminishing expression of several important nerve receptors. BaP also can inhibit differenciation of WBCs into macrophages affecting immune defense. Also intercalates in DNA, binds to guanine and perturbs the helical structure.

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