Glucagon is a hormone that signals through a PKA-mediated pathway in the liver t

Question

Glucagon is a hormone that signals through a PKA-mediated pathway in the liver to stimulate gluconeogenesis and glycogen breakdown.

1) What is the name of the second messenger that activates PKA?

2) The effects of glucagon are opposed by those of another hormone – insulin.   What is the term for the net effect of glucagon vs. insulin on a target cell?

a) Desensitization

b) Modulation

c) Integration

d) Amplification

3) Glucagon is secreted by cells in the pancreas, but acts in the liver. Which of the following general categories of signaling best describes glucagon?

a) Direct

b) Autocrine

c) Endocrine

d) Paracrine

Explanation / Answer

The effects of glucagon are opposed by those of another hormone – insulin.   What is the term for the net effect of glucagon vs. insulin on a target cell

1). cyclic AMP

2. a) Desensitization

3. c) Endocrine

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