Question VI. Rejection of a tumor may involve [complete the sentence and assess

Question

Question VI. Rejection of a tumor may involve [complete the sentence and assess the resulting statements (105-113) as either factually correct (true) or incorrect (false)]:

105. destruction of tumor cells by TNF-a produced by macrophages.
106. destruction of tumor cells by natural killer cells.

107. erythrocyte membranes.
108. complement-dependent cytotoxicity.

109. destruction of tumor cells by phagocytic cells.

110. ADCC.
111. T-cell-mediated cytotoxicity.
112. destruction of tumor cells by megakaryocytes.

113. destruction of tumor cells by eosinophils.

Explanation / Answer

105. False. Studies in mice have shown that TNF-a , is not directly needed for tumor rejection. It is required for generating necrotizing inflammation and necrosis of tumor bearing eyes.

106. True. Natural killer cells are lymphocytes which are activated in response to tumor antigens. These cytotoxic cells contain granzymes (Perforin and proteases) which kill the tumor cells.

107. False

108. True. CDC is involved in tumor rejection in the case of leukamia cell derived HSP70 immunization mice model.

109. True. Phagocytic cells activated by T-cell lymphokines and opsonines target and destroy the tumor cells through enhanced phagocytosis.

110. True. Antibodies can regulate tumor related signalling and can induce antitumor immune responses.

111. True. T cells/T-lymphocytes mediates tumor immunity. Eg: CD8+ T cells, the key effector in antitumor immunity is sustained by CD4+ T cells.

112. False. Megakaryocytes are precursor cells in bone marrow , producing platelets

113. True. The inhibitory role of megakaryocytes in prostrate cell growth in mice is reported.

114. True. Activated eosinophils are necessary for tumor rejection in the presence of tumor specific CD8+ T cells. They initiate macrophage polarization and normalise tumor vessel, hence promote tumor rejection

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