You discover a mutation in anti in a tumor sample. The mutation is within the IA

Question

You discover a mutation in anti in a tumor sample. The mutation is within the IAP binding domain. You are trying to figure out whether you should treat this What should you do and why? Dont bother. The patient will be to the drug since the mutation will prevent activation of the intrinsic pathway. Treat the patient with the drug, it will work to induce apoptosis in the tumor cells and this a good thing Treat the patient with the apoptosis inducing drug because they should be very sensitive due the mutation Dont treat the patient with a drug, we dont want to induce a apoptosis in this patient, they are already sick enough

Explanation / Answer

You discover a mutation in anti-IAPs in a tumor sample. The mutation is within the IAP binding domain. You are trying to figure out whether you should treat the apoptosis . What should you do and why?

Answer :

Treat the patient with the apoptosis inducing drug because they should be very sensitive due the mutation discovered in the antiIAP gene , you expect.

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Explanation:

Inhibitor of Apoptosis (IAP) proteins as medication focuses for the treatment of tumor, inhibitor of apoptosis (IAP) proteins were distinguished by Lois Miller and associates in a screen for baculoviral qualities that could avoid apoptosis of creepy crawly cells tainted with an infection in which the caspase-inhibitory quality p35 was mutated.Increased articulation of these IAPs has been seen in many sorts of disease. For instance, the locus incorporating cIAP1 and cIAP2 is opened up in hepatocellular carcinomas, large amounts of XIAP have been accounted for in cervical growths, and ML-IAP levels are high in melanoma. What's more, cIAP2 is included in translocations found in MALT (mucosa-related lymphoid tissue) lymphomas. Affiliations, for example, these propose that IAPs may be oncogenic, and assuming this is the case, focusing on them pharmaceutically may be restorative,

cytotoxic anticancer medications can actuate apoptosis however these same jolts can bring about rot at higher measurements. At long last, apoptosis is an organized and regularly vitality subordinate process that includes the actuation of a gathering of cysteine proteases called "caspases" and a mind boggling course of occasions that connection the starting stimuli.

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