This question confuses me since it sounds like it\'s an instance of tetanus but

Question

This question confuses me since it sounds like it's an instance of tetanus but I'm not really sure what is happening at a microbiology level.

An explanation would be helpful to this question.

You have stepped on a nail while walking barefoot, place the following five steps that would occur in the process of inflammation in order and determination which would be the third step?

A) The formation of pus at the injury site

B) Release of products from bacteria introduced into the wound as well as chemicals from damaged tissue cells

C) Margination

D) Diapedesis

E)Vasodilation

Explanation / Answer

Stepping on nail while walking calls for acute inflammation.

A) Release of products from bacteria introduced into the wound as well as chemicals from damaged tissue cells act as inflammatory agent.

In response to it various changes occur to bring leukocytes at the injured site to fight against the offending agent.

B) Vasodilation - Responses start with vasodilation, which increases the blood flow carrying plasma proteins and leukocytes at the site of injury. So the inflamed blood vessel is vasodilated.

C) Margination - In vasodilated blood vessel the leukocytes which were present uniformly earlier (before inflammation), now starts to accumulate near the walls of blood vessel but not in contact with the wall. This step is Margination.Then they roll around and stumble at the wall and adheres to the wall firmly.

D) Diapedesis - Finally the leukocytes squeeze out of the blood vessel across the blood vessel wall and reaches to offending agent and acts on it.

E) The formation of pus at the injury site.

After interaction between inflammatory agent and leukocytes pus is formed at the site.

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