1- When bacteria are consumed by macrophages, the macrophages give off chemokine
ID: 176171 • Letter: 1
Question
1- When bacteria are consumed by macrophages, the macrophages give off chemokines to recruit other immune cells. The chemokines serve as ligands for G-protein coupled receptors. Which of the following is NOT true of G-PCRs?
a- GPCRs require GTP for pathway activation.
b- GPCRs bind the ligand extra-cellularly and undergo an allosteric change.
c- The receptor is a G-protein
d- The G-protein is lipid anchored.
2- In some autoimmune disorders, chemokines bind GPCRs to direct immune cells to sites that are not actually foreign invaders. Which of the following might be a treatment for such disorders?
a- A non-hydrolyzable GTP analog
b- A dominant-negative receptor
c- A molecule that constitutively blocks the ligand-binding site.
d- An inhibitor of arrestin.
a- GPCRs require GTP for pathway activation.
b- GPCRs bind the ligand extra-cellularly and undergo an allosteric change.
c- The receptor is a G-protein
d- The G-protein is lipid anchored.
Explanation / Answer
1. G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates and animals
d- The G-protein is lipid anchored.
2. d- An inhibitor of arrestin.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.