Questions 9 and 10: Ligand binding domains of cell surface receptor molecules fa

Question

Questions 9 and 10: Ligand binding domains of cell surface receptor molecules face the outside of the cell.

9. Where is the ligand binding domain of the receptor following receptor mediated endocytosis?

A) on the cytosolic side of endosomal membrane

B) on the cytosolic side of the cell membrane

C) on the luminal side of the endosomal membrane

D) on the cytosolic side of the Golgi membrane

E) on the luminal side of the Golgi membrane

F) on the cytosolic side of the ER membrane

G) on the luminal side of the ER membrane

Question 10: Where is the ligand binding domain of the receptor immediately following translocation?

A) on the cytosolic side of endosomal membrane

B) on the cytosolic side of the cell membrane

C) on the luminal side of the endosomal membrane

D) on the cytosolic side of the Golgi membrane

E) on the luminal side of the Golgi membrane

F) on the cytosolic side of the ER membrane

G) on the luminal side of the ER membrane

Explanation / Answer

9) the ligand-binding domain of the receptor following receptor-mediated endocytosis lies on the [A] on the luminal side of the endosome. endosome is a membrane-bound vesicle formed immediately engulfing the ligand.

10)After translocation, the empty endosome containing only the receptor fuses with gold to resend the receptor back to the cell surface. therefore the answer is option [E] on the luminal side of the golgi membrane.

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