based on the data, what is your major conclusion(s) for each patient? mRNA prote
ID: 176460 • Letter: B
Question
based on the data, what is your major conclusion(s) for each patient?
mRNA
protein
500-1000
1.0-2.0
2000
5
550
1.5
mRNA
protein
200-500
0.5-2.0
1400
3.5
220
0.4
mRNA
protein
300-750
2.0-5.0
6000
20.0
550
2.5
mRNA
protein
50-75
0.5-0.7
55
0.45
60
0.55
mRNA
protein
550-1000
1.0-2.0
520
0.9
600
1.1
mRNA
protein
250-550
2.0-5.0
1500
12
300
2.4
mRNA
protein
50-75
0.1-0.3
200
0.6
60
0.1
enzyme relative abundance average A B GLUT-1mRNA
protein
500-1000
1.0-2.0
2000
5
550
1.5
hexokinase (HK)mRNA
protein
200-500
0.5-2.0
1400
3.5
220
0.4
phosphofructose kinase (PFK)mRNA
protein
300-750
2.0-5.0
6000
20.0
550
2.5
triose phosphate isomerase (TPI)mRNA
protein
50-75
0.5-0.7
55
0.45
60
0.55
glyceraldehyde 3-phosphate dehy. (GAPDH)mRNA
protein
550-1000
1.0-2.0
520
0.9
600
1.1
pyruvate kinase (PK)mRNA
protein
250-550
2.0-5.0
1500
12
300
2.4
lactate dehydrogenase (LDH)mRNA
protein
50-75
0.1-0.3
200
0.6
60
0.1
Explanation / Answer
GLUT 1 facilitates the transport of glucose across mammalian cells. Patient A will have high glucose uptake while patient B uptake will be less as it has lower enzyme levels.
A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate is the most important product.
Phosphofructokinase is a kinase enzyme that phosphorylates fructose 6-phosphate in glycolysis. The patient B has apt levels while the other patient has greater enzyme levels which will lead to faster metabolism which is not good.
Lactate dehydrogenase (LDH) is an enzyme that helps the process of turning sugar into energy for your cells to use. Elevated levels of LDH isoenzymes may indicate :blood flow deficiency,cerebrovascular accident, such as a stroke,certain cancers,heart attack etc. Ptient A will be having these health issues while patient B will be healthy.
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