The following is a proposed mechanism for this reaction: Describe the mechanism
ID: 176556 • Letter: T
Question
The following is a proposed mechanism for this reaction:
Describe the mechanism and indicate why GTP formation is called a substrate level phosphorylation.
g. Succinyl-CoA in the citric acid cycle can also be formed as a result of fatty acid catabolism. What types of fatty acids lead to this metabolite? How is it formed?
h. Succinyl-CoA in the citric acid cycle can be formed as a result of amino acid catabolism as well. Which amino acids give rise to succinyl-CoA? Are these amino acids considered to be glucogenic or ketogenic? Why?
COO CH2 Succinyl CH CoA. OS, S-CoA NH His OH HS-CoA. HS-CoA COO CH2 Succinyl phosphate CH2 intermediate ENA Co-Pao His COO CH2 CH Succinate His HO GDP GTP GDP GTP N NH His
Explanation / Answer
f) Here, GDP takes phosphate from the substrate i.e. phosphorylated histidine itself rather than from any other source, and forms GTP. Such type of phosphorylation is called substrate level phosphorylation.
g) Catabolism of propionyl-CoA gives succinyl Co A. All the odd chain fatty acids catabolize to propionyl Co A which forms succinyl Co A ultimately. It is formed by Beta oxidation of fatty acids.
h) succinyl-CoA is produced from isoleucine, valine, & methionine. They are glucogenic as they form the Kreb cycle's intermediate that can be used to regenerate glucose in need.
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