Human Genetics: Valproic Acid is an anti-seizure medication given to individuals

Question

Human Genetics: Valproic Acid is an anti-seizure medication given to individuals with epilepsy. Valproic Avid has been linked to birth defects involving the heart, fingers, and toes, and closure of the neural tube. When, if ever, can a pregnant woman with epilepsy take valproic acid without harming her unborn child?

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Notes about Retinoic Acid:

Retinoic Acid is a component of a widely prescribed drug called Accutane that's used to treat adult acne. You do not want too much retinoic acid but we have some. This is an example of a drug that can influence embryonic and fetal development

Explanation / Answer

1). Taking valproic acid during the pregnancy increase the risk of developing neural tube defects by 1% or 2%. These children are more likely to suffer from low IQ and autism. This occurs because the valproate decreases the folic acid levels. To prevent this side effect, all the valproic acid using women of childbearing age and those that are planning to conceive must take a high dose folic acid (5 mg/day) throughout the dosage period.

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