Which of the following would NOT constitute a question germane to the completion

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Which of the following would NOT constitute a question germane to the completion of the cell cycle? Are the conditions favorable for cell growth and proliferation? Is all of the DNA free of any damage? Has all of the DNA been replicated at least one or more times? Are all of the chromosomes correctly aligned at the metaphase plate? Irradiating cells usually leads to DNA damage. This causes cells to stop dividing and to arrest at the G1 checkpoint in response. Which of the following events occurs first following DNA damage? Accumulation and Activation of p53 Cyclin Ubiquination Inhibition Cyclin-Cdk Complexes Production of p21

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Part 1: Choice 1 (cellular division and cellular growth are different physiological paramters which require different types of physico-physiological conditions. Cells might divide but do not grow physically due to nutrient deficiency. However, appropriate alignment of chromosomes, replication of DNA and no damage in DNA are absolutely required to proceed the cell into cell division cycle)

Part 2: Choice 1 (p53 is a ubiquitous cytoplasmic anti-proliferative apoptotic protein which gets activated in present of any internal/external stimulus. Transition of this peptide signal from cytoplasm to nucleus drives apoptosis in cells. Since irradiation stress can lead to sudden activation of cytoplasmic proteins, p53 remains the protein which is most effectively and at once activated during such stress)

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