Problem 22.3 One of the main safety issues associated with genetically modified

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Problem 22.3 One of the main safety issues associated with genetically modified crops is the potential for allergenicity caused by introducing an allergen or by changing the level of expression of a host allergen. Based on the observation that common allergenic proteins often contain identical stretches of a few (six or seven) amino acids, researchers developed a method for screening transgenic crops to evaluate potential allergenic properties (Kleter & Peijnenburg, 2002. BMC Struct. Biol. 2: 8). Part A How do you think they accomplished this? Kleter and Peijnenburg determined main amino acids that present in allergenic and transgenic proteins. Kleter and Peijnenburg conducted a series of alignment comparisons of transgenic sequences with sequences of known allergenic proteins. Kleter and Peijnenburg conducted a series of alignment comparisons of transgenic sequences with sequences of hypothetical allergenic proteins. O Kleter and Peijnenburg developed the method of analytical testing for containing the allergenic proteins. Submit My Answers Give Up Continue Provide Feedback

Explanation / Answer

B is the right answer.

Alignments of the transgenic sequences with sequences of allergenic proteins were carried out with the BLAST tool, while limiting the aligned sequences using the limit query "allergen". It should be noted that not all, allergens will be retrieved by the query limit allergen. In addition, some proteins retrieved by this query are not true allergens, such as allergen binding antibodies or sequences that resemble those of allergens. These non-allergenic proteins should not be further considered.

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