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Amino acid oxidation undergoes oxidative catabolism under the following circumst

ID: 177306 • Letter: A

Question

Amino acid oxidation undergoes oxidative catabolism under the following circumstances except: leftover amino acids that are not needed for protein synthesis there are dietary amino acids that exceed body's protein synthesis needed. during starvation in uncontrolled diabetes mellitus right after a meal full of carbohydrates Orotic aciduria is an inherited metabolic disease in which orotate accumulates in the tissues, blood and urine. The metabolic pathway in which the enzyme defect occurs is: Pyrimidine synthesis Pyrimidine breakdown Purine synthesis Purine breakdown Amino acid synthesis During the oxidization of amino acids, the first reaction is to remove the amino group to form alpha-keto acid. Which of the following statements about this reaction is not true? The reaction is catalyzed by aminotransferase All aminotransferases rely on the coenzyme PLP PLP is linked to aminotransferase by hydrogen bonds when the enzyme is in the resting form Typically, a-ketoglutarate accepts amino groups to form glutamate The reaction is reversible

Explanation / Answer

33. Option E

Right after a meal full of carbohydrates

Aminoacid catabolism takes place only if the carbohydrate source is completely depleted. Only then proteins are acted upon.

34. Option A

Pyrimidine biosunthesis - enzyme - uridine monophosphate Synthase

35. Option C

PLP is not linked by hydrogen bonds .

Covalent bonding between PLP and enzyme’s active site and also through strong noncovalent interactions . There is also an imine (Schiff-base) linkage to the -amino group of a Lys residue.

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