Suppose three different genes: D, E, and F, all unlinked to each other, are know

Question

Suppose three different genes: D, E, and F, all unlinked to each other, are known to control the predisposition towards heart disease. Using the P() notation to show how you would calculate the probabilities requested below. (ex: "Probabiity that a person is mutant in D" = "P(D-)").

a) Suppose that a person is predisposed only if all three loci are mutant. What is the probability of that occuring?

b) Suppose that a person is predisposed if any of the three loci are mutant. What is the probability of that occurring?

c) Suppose is the probability that a person is not mutant in D?

d) Suppose that a person is not mutant in all three loci?

Hint: If you couldn't figure out b, try it again and use d as a starting point.

Explanation / Answer

a. P (D’) x P (E’) x P (F’), where D’, E’ and F’ are mutant form of each.

b. P (D’) + P (E’) + P (F’)

c. P (1-D)

d. 1 – P (ALL), where P (ALL) = P (D’E’F’)

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