A man and woman have a child with Leach Nyman syndrome. He is profoundly retarde

Question

A man and woman have a child with Leach Nyman syndrome. He is profoundly retarded and compulsively bites his lips and fingers to the point that he must be restrained. Leach Nyman is sex-linked recessive; affected individuals typically die in their teens from kidney failure. What are the chances that another son of this couple will inherit Leach Nyman syndrome? What are the chances that a daughter of this couple will inherit Leach Nyman? The couple decides to undergo in vitro fertilization. A copy of the human SRY gene is tagged with a radioactive chemical and applied to 8 pre-embryo from this couple which is growing in the laboratory dish. The probe lights up in 6 of the embryos. The couple has one of the remaining embryos, which lacks the SRY gene, implanted to continue the pregnancy. Why did the parents select the embryo without the SRY gene top continue development? What is the chance that any of the pre-embryo that does not have the SRY gene, if allowed to continue developing, would produce a child with Leach Nyman syndrome?

Explanation / Answer

There is a 50% chance to get Lesch-Nyhan syndrome for another son, because it is X-lined, half of sons will get affected with the syndrome.

No chance to get the syndrome because her father does't have this syndrome. But there is 50% chance that the daughter will become carrier for the syndrome.

SRY gene present in only males, not in females. To avoid the risk of getting son with Lesch-Nyhan syndrome, they selected the embryo which is not expressing SRY gene, the whom become develop as a female with no syndrome.

They will get daughter child with no chance of getting syndrome.

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