Shown below are the amino acid sequences of the wild-type and three mutant forms

Question

Shown below are the amino acid sequences of the wild-type and three mutant forms of a short protein.

What type of mutation does each represent (missense, nonsense etc)?

Specifically what change occurred in the mRNA sequence to result in the change in the amino acid sequence?

A fourth mutation in the gene is isolated. Analysis of the new mutation shows that the protein encoded has the wild-type sequence, but the amount of the protein produced is 50% higher than the normal amount. Where would you predict the mutation is located in this strain?

Wild type:     met-trp-tyr-arg-gly-lys-pro-thr

Mutant 1:      met-trp-cys-arg-gly-lys-pro-thr

Mutant 2:      met-trp-tyr-arg-arg-gln-ala-asp

Mutant 3:      met-trp-tyr-arg

Explanation / Answer

Mutant 1= missense mutation.

Mutant 2: Frameshift mutation due to addition of nucleotide in front of codon GGC.

Mutant 3: Non sense mutation.

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