Question 4 (1pt). The ribosome contains three zones that can be occupied by tRNA

Question

Question 4 (1pt). The ribosome contains three zones that can be occupied by tRNA molecules: the A, P and E channels. During translation initiation, how is the initiator tRNA prevented from entering the ribosome through the A and E channels?

A. The physical dimensions of the A and E channels are too small for the initiator tRNA to enter.
B. Translation initiation factors such as IF1 and IF1A (in eukaryotes) will enter and block the A and E channels.

C. The ribosomal subunits that comprise the E and A channels are not added to the small ribosomal subunit until after the initiator tRNA is inserted into the P channel.
D. The initiator tRNA can actually enter any of the three channels but it will be moved to the P channel by several initiation factors.

Explanation / Answer

B. Translation initiation factors such as IF1 and IF1A (in eukaryotes) will enter and block the A and E channels.

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