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1. When Na+-channel is opened in a receptor, it will lead to a. depolarization b

ID: 177591 • Letter: 1

Question

1. When Na+-channel is opened in a receptor, it will lead to

a. depolarization

b. hyperpolarization

c. repolarization

d. polarization

e. neurotransmitter release

2. When Cl–-channel is opened in the post-synaptic receptor, the

synapse would be

a. an excitatory synapse.

b. an inhibitory synapse.

c. a neutral synapse.

d. an electrical synapse.

e. non-functional synapse.

3. Which receptor is known to be involved in synaptic plasticity that

induces long-term potentiation (LTP)?

a. NMDA glutamate receptor

b. non-NMDA glutamate receptor

c. GABAA receptor

d. mu-opioid receptor

e. nicotinic-ACh receptor

4. Which receptor does barbiturate or diazepam (Valium™) bind to?

a. serotonin receptor

b. norepinephrine receptor

c. opioid receptor

d. NMDA receptor

e. GABAA receptor

5. Which part of the brain does opioid receptors are found where it

regulates the emotional influence of pain perception?

a. basal ganglia

b. cerebellum

c. cortex

d. medial thalamus

e. septal nucleus

6. Which neurotransmitter binds to the CB-receptor (cannabinoid

receptor)?

a. opioid

b. nitric oxide

c. serotonin

d. anandamide

e. acetylcholine

7. Which neurotransmitter (or neuromodulator) is released that

stimulates the parasympathetic system in the erectile response

(which Viagra™ potentiates)?

a. acetylcholine

b. substance P

c. nitric oxide

d. cannabinoid

e. norepinephrine

8. Which receptor is targeted to enhance the inhibition in the

amygdala to produce the anti-anxiety effect in the design of antianxiety

drug treatment?

a. glutamate receptor

b. GABA receptor

c. cananbinoid receptor

d. opioid receptor

e. dopamine receptor

9. Which receptor is targeted to enhance the prefrontal cortex (PFC)

executive function to treat ADHD/ADD?

a. dopamine D4 receptor

b. serotonin receptor

c. NMDA glutamate receptor

d. GABAB receptor

e. nicotinic ACh receptor

10. What is the signal that triggers the vesicular release of

neurotransmitter when action potential arrives at the axon

terminal?

a. Increase in the cytoplasmic concentration of neurotransmitters.

b. Binding of amphetamine to the VMAT.

c. Binding of amphetamine to the transporter.

d. Na+ ion entry into the axon terminal.

e. Ca++ ion entry into the axon terminal.

11. Which experiment is used to prove that release of dopamine

induced by amphetamine is not coming from vesicular release?

a. dopamine is released by activation of action potentials in the

presynaptic neuron without amphetamine.

b. dopamine release only in the presence of magnesium.

c. dopamine release is dependent on depolarization of post-synaptic cell.

d. dopamine release from axon terminal can occur in Ca++ free medium.

e. dopamine release is quantal in amount.

12. Which drug can stimulate the sympathomimetic effects?

a. MDMA

b. Valium™

c. Prozac™

d. amphetamine

e. nicotine

Explanation / Answer

Ans. A

The opening of channels that let positive ions flow into the cell can cause depolarization. Example: Opening of channels that let Na+ into the cell

2 Ans an inhibitory synapse.