The Rb- mutation responsible for Retinoblastoma is a recessive allele of a tumor

Question

The Rb- mutation responsible for Retinoblastoma is a recessive allele of a tumor suppressor found on chromosome 13. What process is likely to lead to a loss of heterozygosity in Rb-/Rb+ individuals so that they develop tumors?

A) Meiotic non-disjunction leading to a monosomy

B)  Mitotic recombination leading to homozygous daughter cells

C) Spontaneous somatic point mutations in the Rb+ copy

D) Mitotic nondisjunction leading to an aneuploid hemizygote

E) Both mitotic non-disjunction or mitotic recombination are possible reasons

Explanation / Answer

Mitotic crossovers that lead to homozygosity for both RB+ and RB- and a somatic mutation in the RB+ allele that leads to homozygosity for RB-. Therefore the answer will be E.

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