Choose three genes associated with your ovarian cancer below. Answer the followi

Question

Choose three genes associated with your ovarian cancer below. Answer the following questions for each gene.

• What is the function of the gene? •

Is this a tumor suppressor or proto-oncogene? Why?

• Which hallmarks are associated with the gene? If there are no hallmarks explain how the gene relates to cancer. •

Find a molecular diagram related to the role of this gene in cancer. Create a linear molecular diagram of the illustrated pathway.

• Where would you intervene for a targeted therapeutic approach? – Would you activate or inhibit this target?

Ovarian Cancer • AKT1 • CDH1 • PTEN • TP53 • RAD50 • RB1

Explanation / Answer

Choose three genes associated with your ovarian cancer below. Answer the following questions for each gene.

What is the function of the gene?

Ovarian cancer, the most lethal tumor in gynecologic cancers, is the fifth most cause of cancer-related deaths among women. According to cancer statistics, approximately 21,290 women will be diagnosed and 14,180 will die due to ovarian cancer in the United States in 2015.

CDH1: CDH1, a tumor suppressor gene, also called as epithelial cadherin (E-cadherin) and cadherin-1. CDH1, a member of the cadherin family, plays an important role in epithelial cell-cell adhesion and in maintaining normal tissue architecture. The reduction of CDH1 expression may involve in invasion and metastasis of ovarian cancers.

RAD50: RAD50 is a suitable candidate gene for predisposition to the ovarian and breast cancers.

PTEN: The phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene encodes a tumor suppressor phosphatase that has recently been found to be frequently mutated in patients with endometriosis, endometrial cancer, and ovarian cancer.

Is this a tumor suppressor or proto-oncogene? Why?

CDHI and PTEN are tumor suppressor genes. In contrast, RAD-50 is a proto-oncogene.

Which hallmarks are associated with the gene? If there are no hallmarks explain how the gene relates to cancer. •

Find a molecular diagram related to the role of this gene in cancer. Create a linear molecular diagram of the illustrated pathway.

Where would you intervene for a targeted therapeutic approach? – Would you activate or inhibit this target?

Inhibition of the proto-oncogenes is quite a reliable method to prevent many cancers but there are other complications.

Ovarian Cancer • AKT1 • CDH1 • PTEN • TP53 • RAD50 • RB1

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